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Ivermectin in India, Prophylactic role of ivermectin in SARS-CoV-2 infection among healthcare workers.

Background

Healthcare workers (HCWs) are vulnerable to getting infected withSARS-CoV-2.

Preventing HCWs from getting infected is a priority to maintain healthcare services.

The therapeutic and preventive role of ivermectin in COVID-19 is being investigated.

Based on promising results of in vitro studies of oral ivermectin, this study to look at prophylactic role of oral ivermectin.

Methods

Prospective cohort study was conducted at AIIMS Bhubaneswar.

Two-doses of oral ivermectin, 300 μg/kg at a gap of 72 hours.

Primary outcome, COVID-19 infection in the month following.

Of 3892 employees, 3532 (90.8%) participated in the study.

Conclusion and relevance

Two-doses of oral ivermectin (300 μg/kg given 72 hours apart) as chemoprophylaxis among HCWs

reduces the risk of COVID-19 infection by 83% in the following month.

Safe, effective, and low-cost chemoprophylaxis have relevance in the containment of pandemic
alongside vaccine.